Laboratory Information Management System (LIMS) is software used in a laboratory for the management of samples, laboratory users, instruments, standards, and other laboratory functions such as invoicing, plate management, and workflow automation. At its core, LIMS software serves to automate the labor-intensive clerical activities associated with the processing of laboratory results to improve the accuracy and the turnaround time of results. Automation of laboratory activities removes the element of manual reporting, increases productivity, and allows access to retrospective data for analysis. The global market for LIMS is expanding. According to one estimate, 1 this market is expected to reach $2.12 billion by 2021 from $1.37 billion in 2016, at an annual growth rate of 9.1%. The growth in the LIMS market is driven by the increasing demand for quality laboratory diagnosis, government initiatives to support health surveillance for effective disease prevention, and reliable case confirmation during pandemic outbreaks. To increase the resilience, reuse, and sustainability of open-source LIMS software, we propose enhancing the interoperability, security, and quality control of SENAITE (formerly known as Bika LIMS), 2 the leading open-source LIMS platform. This proposal is designed to provide support to an existing global good to ensure that it is properly resourced for sustained development.